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Objective To investigate the multiparametric magnetic resonance technique in diagnosis of bladder urothelial carcinoma. Methods The clinical data of 80 patients with urinary tract disease who were treat-ed in the Department of Urology in our hospital from October 2016 to March 2017 were analyzed.The patients were divided into two groups:the tumor group(39 patients with bladder cancer)and the control group(41 patients with the remaining bladder disease).The basic information of two groups and pathological diagnosis results were record-ed and analyzed. Multivariate logistic regression analysis was performed to screen out the statistical significance of the diagnosis of bladder cancer. The ROC curve was applied to determine the best diagnostic point. Results The multivariate analysis showed that UBC level(P=0.039),NMP22(P=0.038)and ADC(P=0.028)have signifi-cance in diagnosis of bladder cancer. Pearson analysis showed that there was a significant correlation between the ADC value and the NMP22(r = 0.333,P = 0.038). The ROC curve shows that the ADC area under the ROC curve was 0.750. The diagnostic sensitivity of ADC value was 0.9750 × 10-3mm2/s;The diagnostic sensitivity was 73.2% and specificity was 69.2%. Conclusion Multiparametric magnetic resonance imaging is of great value in the diagnosis of bladder cancer.
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OBJECTIVE:To improve the efficacy and safety of high dose methotrexate (HDMTX)chemotherapy in the treatment of children with acute lymphoblastic leukemia through blood concentration monitoring.METHODS:27 children with acute lymphoblastic leukemia who received high dose of HDMTX (1.5～4.0 g/m2)for 55 times were involved in this study,the blood samples were collected timely and the blood concentration of methotrexate was determined,the efficacy of the chemotherapy was evaluated according to blood MTX concentration at the ending of its intravenous drip (12h),the calcium folinate relief scheme was determined from the MTX serum concentration in terminal elimination phase.RESULTS: The times for 2.0 g/m2,3.0 g/m2 and 4.0 g/m2 different dosage of methotrexate groups with blood concentration maintained above osmotic concentration(2?10-5mol/L)at the end of intravenous drip (12h)were respectively 75%,92.1%and 100%of the total chemotherapy times.Only one patient was observed with large area of impairment of skin and mucosa,and no severe irreversible adverse reaction were observed in the other cases.CONCLUSIONS: MTX serum concentration monitoring is helpful for mastering the rational rescue dosage of MTX and calcium folinate so as to ensure the efficacy and safety of the chemotherapy.
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0.05).Conclusion:The abnormal expression of HLA-G protein in eutopic and ectopic endometrium tissues may play a key role in the pathogenesis of adenomyosis.